Screening and Monitoring Studies

The NAPLS Study is focused on learning about how concerns about mental health develop or get better during adolescence and young adulthood. Your involvement may help us learn about how certain kinds of mental health problems begin, how to predict who may be most at risk and therefore in need of early treatment, and who is most likely to improve over time.

For more information, please contact Megan Graham at (617) 754-1223 or This e-mail address is being protected from spambots. You need JavaScript enabled to view it


Who Can Participate?

We are looking for adolescents or young adults ages 12-35 who have experienced some new or worsening concerns in the past year, including:

  • Worrisome decline in academic, work, or social functioning
  • Suspiciousness or uneasiness with others
  • Unusual ideas or behavior
  • Increased sensitivity to sights/sounds, or mistaking noises for voices or messages
  • Feeling more anxious, depressed, or out of touch
  • Feeling like your mind is playing tricks on you


What's Involved?

After an initial evaluation to determine if you are eligible, you will participate in an in-depth assessment. This will be followed by continued monitoring assessments at 2, 4, 6, 8, 12, 18, and 24 months (or sooner if problems worsen). Each assessment will involve one or more visists to our clinics.

Assessments will include personal interviews about your history and experiences; brain Magnetic Resonance Imaging (MRI) scan; collection of urine, blood, and saliva; paper and pencil tests of cognition; and brain electroencephalogram (EEG). We will also ask for your permission to conduct an interview with a family member at baseline to better understand your family history.

Participation is free and confidential, and subjects will be compensated for their participation.

Compensation up to $1,860 for completion of 2 year study.

Feedback, Monitoring, and Treatment

The baseline evaluation includes a comprehensive assessment. After this evaluation, study staff will provide feedback to participants, their families, and--with permission--to doctors, clinicians, and/or school personnel. We will also evaluate and monitor your status at each visit and, if indicated, provide additional feedback if concerns worsen. If abnormalities are detected using MRI or EEG, this will also be shared with you.

Once in the study, all participants will be offered an optional three-session, family-based psychoeducation treatment and, if needed, additional crisis management sessions. If indicated, additional recommendations and referrals for treatment will be made, including to the CEDAR clinic.


Download NAPLS Brochure