Screening and Monitoring Study

NAPLS III Study: Mental Health and Brain Development in Youth and Young Adults

A monitoring study of thoughts, feelings, and behaviors for adolescents and young adults.

For More Information or to Participate:

Complete an online self-referral form: < RedCap Survey >

To contact us and ask about NAPLS: < Referral Process >

To learn more: < Download NAPLS Brochure >



Why Participate in Research?

Participating in research studies like the NAPLS III Study allows participants to become more educated on their illness. It also allows participants to have a more involved role in their healthcare, as well as helps contribute to research that could possibly lead to medical innovations and more effective treatments.

Why is Mental Health Research Important?

Understanding mental illness can lead to improvements in caring for individuals. Mental health research is the first step toward new, more effective treatments and ultimately possible prevention for people who may be at risk for illness. Your participation may help us to learn how certain kinds of mental health concerns begin and how to identify those most at risk and in need of early treatment.

What will happen during the study?

As a participant, you would be asked to:
Sign a consent form indicating your agreement to participate in the 2 year study.


Procedures include:


Screening evaluation

· Initial eligibility screening evaluation with a clinician to discuss your history & any changes in your thinking, feelings & behavior


Baseline, 2-, 4-, 6-, and 8-month assessments which include:

· Personal interviews about your history, experiences, & recent changes

· Collection of urine, saliva, & blood

· Paper & pencil tests of cognitive abilities (attention, memory, etc.)

· Brain magnetic resonance imaging (MRI) scan

· Electroencephalogram (EEG) of your brain (brainwaves)


Follow-up assessments at 18-, and 24– months from baseline will include:

· Personal interviews about your history, experiences, & recent changes

· Collection of urine & blood

Who can participate?

Eligible for the study are adolescents or young adults (ages 12-35) with difficulties that have begun or worsened in the past year such as:

· worrisome drop in grades or work performance

· having trouble thinking clearly, focusing, or concentrating

· suspiciousness or uneasiness with others

· decline in self-care or personal hygiene

· withdrawal from friends or family

· having ideas that others may find unusual or too intense

· having strange feelings or no feelings at all

· feeling like your mind is playing tricks on you

· increased sensitivity to sights or sounds

· mistaking noise for voices or messages

Excluded from the study are people with mental retardation and people with serious medical conditions or prolonged problematic drug or alcohol use.

This study takes place at Massachusetts Mental Health Center and Beth Israel Deaconess Medical Center, East Campus. Individuals will be compensated for completion of study assessments ($40 for the screening evaluation and, for eligible participants, up to approximately $2,000 across the 2-year study). All assessments are free of charge.


Principal Investigator: William Stone, Ph.D.

Project Director: Michelle West, PhD